Cultural change in organizations is an adventurous journey in itself, which needs people who are willing to take advantage, prepared to collaborate and ready to change and take the lead. There are many possible routes to take when initiators and leaders decide to challenge and change organizational cultures. This final part helps leaders in cultural change to choose their way in successful organizational change. The first part of this text focuses on trajectories for cultural change in organizations based on eight different routes. These routes may be combined in a coherent journey to create new business ideas and contribute to the success of organizations. The routes in this chapter characterize the paths followed by successful leaders in cultural change together with people in their organizations. A clear perspective of the routes for change contributes to the success of changes. The second part of this text brings together the essentials of cultural change and leadership in organizations. Guiding principles and success factors for cultural change are summarized which are helpful to be a successful leader in cultural change in organizations.